Index Catalog // Arch : Northwestern University Institutional Repository

MNK-eIF4E Signaling and mRNA Translation Regulate Mesenchymal Glioma Stem Cell Maintenance and Promote Therapeutic Resistance in Glioblastoma

Description:: MAPK-interacting kinase (MNK) signaling leads to activation of cap-dependent mRNA translation through phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E). In cancer cells, MNK-eIF4E signaling promotes translation of oncogenic mRNAs. In glioblastoma (GBM), the deadliest malignant brain tumor, MNK-eIF4E signaling is aberrantly activated and represents a promising therapeutic target....
Keyword:: MAPK-interacting kinase, Glioblastoma, and Glioma stem cells
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Jonathan Brooks Bell
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/26/2018
Date Modified:: 10/26/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

Overcoming Temozolomide Resistance in Glioblastoma Multiforme with MGMT-Targeting Spherical Nucleic Acids

Description:: Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system malignancy. Due to the aggressive nature of these tumors and our inability to adequately treat them, only 3-5% of patients survive longer than 3 years post-diagnosis. The standard of care for newly diagnosed GBM is surgical resection followed by...
Keyword:: siRNA, Ribozyme, Glioblastoma, Spherical nucleic acids, Gold nanoparticles, and MGMT
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Timothy L. Sita
Owner:: Scholarly Digital Publishing
Date Uploaded:: 03/12/2018
Date Modified:: 03/12/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

Targeting Senescent Cells to Improve Immunotherapeutic Efficacy in Older Adults with Glioblastoma

Description:: Glioblastoma (GBM) is the most common aggressive primary malignant brain tumorin adults with a median age of onset of 65 years of age. Although advanced age is often associated with worse GBM patient survival, the predominant source(s) of maladaptive aging effects remains to be established. Here we studied intra-tumoral and...
Keyword:: Senescence, p16INK4a, Glioblastoma, Aging, and Immunotherapy
Subject:: Biology and Neurosciences
Creator:: Bell, April Charlotte
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16795 and etdadmin_upload_1016132

Isocitrate Dehydrogenase 3 and One-Carbon Metabolism: Defining a Novel Role for Isocitrate Dehydrogenase 3 in Glioblastoma

Description:: Glioblastoma (GBM) is a highly malignant brain tumor that accounts for the most commonly diagnosed type of primary brain tumors in adults. It has a poor prognosis of only 15 months from the time of diagnosis. The gold standard therapy regimen consists of radiotherapy and the chemotherapeutic temozolomide. Both of...
Keyword:: Isocitrate Dehydrogenase, Glioblastoma, cancer, one-carbon metabolism, metabolism, and cytosolic serine hydroxymethyltransferase
Subject:: Cellular biology
Creator:: May, Jasmine Louise
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_593360 and http://dissertations.umi.com/northwestern:14231

Defining and Therapeutically Targeting IDH1-WT Oncogenicity in GBM

Description:: Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system tumor, characterized by resistance to therapeutic intervention, inevitable recurrence, and ultimately patient death. The dismal prognosis is due in part to underlying molecular factors that promote an intratumoral cellular state heterogeneity and protect tumor cells from cell death pathways....
Keyword:: Ferroptosis, Glioblastoma, Cancer, Stemness, Metabolism, and IDH1
Subject:: Molecular biology, Medicine, and Neurosciences
Creator:: Murnan, Kevin Michael
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15885 and etdadmin_upload_865864

LY6K Promotes Glioblastoma Tumorigenicity via CAV-1-Mediated ERK1/2 Signaling Enhancement

Description:: Background: Glioblastoma (GBM) tumors are the most malignant brain cancers and are characterized as Grade IV astrocytomas by the World Health Organization. GBM tumors can be classified into three molecular subtypes known as proneural, classical, and mesenchymal. In addition, GBM tumors also have a small population of cells known as...
Keyword:: LY6K, Methylation, Glioblastoma, ERK1/2, and CAV-1
Subject:: Molecular biology, Oncology, and Neurosciences
Creator:: Sastry, Namratha G
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_733180 and http://dissertations.umi.com/northwestern:15049

Molecular Diversity in Human Pluripotent Stem Cell Derived Astrocyte Progenitors and their Association with Subtypes of Glioblastoma

Description:: Astrocytes are the most abundant cell type in the brain, yet the mechanisms involved in astrocyte differentiation and the level of astrocyte heterogeneity in the CNS, particularly in the human cortex, is largely unknown due to the lack of subtype-specific astrocyte markers and inaccessibility of human brain tissue. Here we...
Keyword:: Glioblastoma, Stem cells, and Astrocyte
Subject:: Neurosciences
Creator:: Van Gulden, Stephanie
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15549 and etdadmin_upload_817717

Synthesis and Development of Natural and Rationally-Designed Chemical Probes for the Investigation and Perturbation of Biological Pathways

Description:: Biologically active small molecules remain the foundation for the medical management of human disease. Their impacts on human health, longevity, culture, and society are difficultly overstated. In large part, medicines derived from organic compounds are the result of the tireless efforts of chemical practitioners––both past and present––who have dedicated much...
Keyword:: Mellpaladine A, Glioblastoma, Autophagy, MAP2K7, and T-ALL
Subject:: Organic chemistry and Cellular biology
Creator:: Kim, Dalton Robert
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16465 and etdadmin_upload_977054

Defining and Altering the Natural Trajectories of Glioma: Seizures and Brainstem Infiltration

Description:: Multiple facets of the natural trajectory of glioma remain poorly understood, which results in a universally poor prognosis for patients with glioma. Many patients with glioma experience tumor-associated epilepsy (TAE) throughout their disease course, but the mechanism by which TAE occurs, who is at continued risk for TAE, and whether...
Keyword:: Glioma, Glioblastoma, Infiltration, IDH, and Seizure
Subject:: Oncology and Cellular biology
Creator:: Drumm, Michael Raymond
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16570 and etdadmin_upload_985850

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MNK-eIF4E Signaling and mRNA Translation Regulate Mesenchymal Glioma Stem Cell Maintenance and Promote Therapeutic Resistance in Glioblastoma

Overcoming Temozolomide Resistance in Glioblastoma Multiforme with MGMT-Targeting Spherical Nucleic Acids

Targeting Senescent Cells to Improve Immunotherapeutic Efficacy in Older Adults with Glioblastoma

Isocitrate Dehydrogenase 3 and One-Carbon Metabolism: Defining a Novel Role for Isocitrate Dehydrogenase 3 in Glioblastoma

Defining and Therapeutically Targeting IDH1-WT Oncogenicity in GBM

LY6K Promotes Glioblastoma Tumorigenicity via CAV-1-Mediated ERK1/2 Signaling Enhancement

Molecular Diversity in Human Pluripotent Stem Cell Derived Astrocyte Progenitors and their Association with Subtypes of Glioblastoma

Synthesis and Development of Natural and Rationally-Designed Chemical Probes for the Investigation and Perturbation of Biological Pathways

Defining and Altering the Natural Trajectories of Glioma: Seizures and Brainstem Infiltration

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