Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Glioblastoma (GBM) is the most common aggressive primary malignant brain tumorin adults with a median age of onset of 65 years of age. Although advanced age is often associated with worse GBM patient survival, the predominant source(s) of maladaptive aging effects remains to be established. Here we studied intra-tumoral and...
Keyword:: Senescence, p16INK4a, Glioblastoma, Aging, and Immunotherapy
Subject:: Biology and Neurosciences
Creator:: Bell, April Charlotte
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16795 and etdadmin_upload_1016132

Description:: Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system tumor, characterized by resistance to therapeutic intervention, inevitable recurrence, and ultimately patient death. The dismal prognosis is due in part to underlying molecular factors that promote an intratumoral cellular state heterogeneity and protect tumor cells from cell death pathways....
Keyword:: Ferroptosis, Glioblastoma, Cancer, Stemness, Metabolism, and IDH1
Subject:: Molecular biology, Medicine, and Neurosciences
Creator:: Murnan, Kevin Michael
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15885 and etdadmin_upload_865864

Description:: Astrocytes are the most abundant cell type in the brain, yet the mechanisms involved in astrocyte differentiation and the level of astrocyte heterogeneity in the CNS, particularly in the human cortex, is largely unknown due to the lack of subtype-specific astrocyte markers and inaccessibility of human brain tissue. Here we...
Keyword:: Glioblastoma, Stem cells, and Astrocyte
Subject:: Neurosciences
Creator:: Van Gulden, Stephanie
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15549 and etdadmin_upload_817717

Description:: Background: Glioblastoma (GBM) tumors are the most malignant brain cancers and are characterized as Grade IV astrocytomas by the World Health Organization. GBM tumors can be classified into three molecular subtypes known as proneural, classical, and mesenchymal. In addition, GBM tumors also have a small population of cells known as...
Keyword:: LY6K, Methylation, Glioblastoma, ERK1/2, and CAV-1
Subject:: Molecular biology, Oncology, and Neurosciences
Creator:: Sastry, Namratha G
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_733180 and http://dissertations.umi.com/northwestern:15049

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