Northwestern University

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Filtering by: Keyword Glioblastoma (GBM) Keyword targeted therapy

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Cancer-Associated Isocitrate Dehydrogenase 1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Description:

Metabolic abnormalities of cancers provide opportunities for novel tumor-specific therapies. Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate (αKG) and the reduction of NAD(P)+ to NAD(P)H. Oncogenic mutations in two IDH-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and secondary glioblastoma...

Keyword:

lipids, Glioblastoma (GBM), targeted therapy, wild-type IDH1, NADPH, and metabolism

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Andrea Calvert

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/27/2018

Date Modified:

04/27/2018

Date Created:

2017-01-01

Resource Type:

Dissertation