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The TRIP8b-HCN Interaction as a Therapeutic Target

Description:

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed in the heart and central nervous system where they regulate membrane excitability. Recently, inhibiting HCN channels in the hippocampus has been identified as a possible therapeutic intervention for the treatment of Major Depressive Disorder (MDD). However, based on the high expression level of...

Keyword:

HCN, OPC, Oligodendrocyte, TRIP8b, and Depression

Subject:

Neuroscience, Biochemistry, and Developmental Biology

Creator:

Kyle Andrew Lyman

Owner:

Scholarly Digital Publishing

Date Uploaded:

06/17/2019

Date Modified:

06/17/2019

Date Created:

2016-01-01

Resource Type:

Dissertation

Alternate Identifier:

https://doi.org/10.21985/N2W781
Role of HCN channels in Behavioral Responses to Psychosocial Stress

Description:

Psychosocial stress is part of everyday life, and while ubiquitous, stress plays a huge role disease development and treatment. Though the stressor’s intensity, predictability, and frequency (acute vs chronic) are important determinants of disease development, interactions with one’s genetic and epigenetic make-up also play a causal role. Major Depressive Disorder...

Keyword:

coping, HCN, Hyperpolarization activated current, gastrointestinal motilit, stress, and mice

Subject:

Interdepartmental Neuroscience Program (NUIN)

Creator:

Daniel W. Fisher

Owner:

Scholarly Digital Publishing

Date Uploaded:

01/23/2019

Date Modified:

01/23/2019

Date Created:

2017-01-01

Resource Type:

Dissertation

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The TRIP8b-HCN Interaction as a Therapeutic Target

Role of HCN channels in Behavioral Responses to Psychosocial Stress

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