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An Investigation of the Cellular Mechanisms Underlying Hearing Sensitivity and Resistance to Noise Induced Traumas.

Description:

Perturbations to the physiology or impairments in the formation of synapses within the cochlea, specifically the ribbon synapses, result in decreased sensitivity to auditory stimuli. In example, prolonged exposure to moderately intense auditory stimuli, like power tools, can result in the swelling of nerve terminals, retraction of the postsynaptic membrane,...

Keyword:

Hearing, Neuroligins, Proteomics, Ribbon Synapse, ASD, and NIHL

Subject:

Neurosciences

Creator:

Ramirez, Miguel Angel

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

09/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16120 and etdadmin_upload_909763
Roles of Specialized Mucolipin-Endowed Lysosomes

Description:

Mucolipins are lysosomal cation channels, with high permeability to calcium ions, that are thought to regulate endolysosomal trafficking. While mucolipin 1 is expressed in all cells, mucolipin 3 is expressed in a small subset of cells (i.e. neonatal intestinal enterocytes, cochlear hair cells and marginal cells of stria vascularis). This...

Keyword:

Hearing, Enterocyte, Trpml, Lysosome, Mucolipin, and NEC

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Teerawat Wiwatpanit

Owner:

Scholarly Digital Publishing

Date Uploaded:

02/18/2019

Date Modified:

02/18/2019

Date Created:

2018-01-01

Resource Type:

Dissertation

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An Investigation of the Cellular Mechanisms Underlying Hearing Sensitivity and Resistance to Noise Induced Traumas.

Roles of Specialized Mucolipin-Endowed Lysosomes

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