Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Bacterial infections (BI) are a frequent, expensive, and life-threatening condition for critically ill patients. For patients with serious BI, minimizing the time between admission to the intensive care unit (ICU) and administration of appropriate antibiotic therapy is crucial to improve prognosis. However, the current gold-standard for identifying the appropriate antimicrobials...
Keyword:: MIMIC, Antibiotic Stewardship, Clinical Prediction, Critical Care, Machine Learning, and Electronic Health Records
Subject:: Icelandic & Scandinavian literature and Bioinformatics
Creator:: Eickelberg, Garrett
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_999752 and http://dissertations.umi.com/northwestern:16645

Description:: Breakthroughs in large-scale biological data collection have resulted in a wealth of -omics (genomics, metabolomics, etc.) datasets in the literature. However, the development of appropriate computational techniques for their analysis is lacking, yet crucial for fully extracting the rich information contained in these datasets. The work in this dissertation describes...
Keyword:: Biorecording, Data Storage, Cheminformatics, Metabolomics Annotation, Machine Learning, and TdT
Subject:: Bioengineering, Bioinformatics, and Biochemistry
Creator:: Strutz, Jonathan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_911481 and http://dissertations.umi.com/northwestern:16126

Description:: Mammalian transcriptional regulation is well-known to be complex and highly context dependent. Different genetic and epigenetic features, including single nucleotide polymorphisms (SNPs) that function as cis- or trans-expression quantitative trait loci (eQTLs), transcription factor (TF) interaction profile with cis-regulatory elements (CREs), methylation of CpG dinucleotide sequences, and histone modification that...
Keyword:: Bioinformatics, Transcriptomics, Gene regulation, Deep Learning, Machine Learning, and Drug discovery
Subject:: Bioinformatics, Genetics, and Oncology
Creator:: Ji, Yanrong
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_818497 and http://dissertations.umi.com/northwestern:15562

Description:: Annual age-adjusted breast cancer incidence rates in the United States have been static for decades. More recently, the development of massively parallel, high throughput DNA sequencing has enabled the cataloging of somatic mutations in cancer. Mutations are non-random and occur within sequence motifs. These motifs provide us with evidence to...
Keyword:: Natural Language Processing, Electronic Health Records, Genomics, Mutational Processes, Breast Cancer, and Machine Learning
Subject:: Bioinformatics and Computer science
Creator:: Zeng, Zexian
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14500 and etdadmin_upload_635668

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