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HEXOKINASE 1 SUBCELLULAR LOCALIZATION REGULATES THE METABOLIC FATE OF GLUCOSE

Description:

The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...

Keyword:

Inflammation, Hexokinase, Macrophage, Subcellular localization, Metabolism, and Mitochondria

Subject:

Biology

Creator:

De Jesus, Adam

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_773389 and http://dissertations.umi.com/northwestern:15348
Mechanisms of Macrophage-Directed Inflammation Resolution

Description:

Efferocytosis is the anti-inflammatory removal of dying cells and cellular debris, occurring billions of times per person, per day as a part of homeostatic maintenance during natural cell turnover. Macrophages are major professional phagocytes of the immune system and are responsible for dead cell clearance during infection and injury. During...

Keyword:

CD36, HIF, Macrophage, and Efferocytosis

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Shirley Dehn

Owner:

Scholarly Digital Publishing

Date Uploaded:

10/09/2018

Date Modified:

10/09/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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HEXOKINASE 1 SUBCELLULAR LOCALIZATION REGULATES THE METABOLIC FATE OF GLUCOSE

Mechanisms of Macrophage-Directed Inflammation Resolution

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