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High-Throughput Discovery of Natural Products Using Hundreds of Bacterial Genomes and a Correlative Method

Description:

Natural products provide a renewable resource of novel chemical structures with relevance to the pharmaceutical, agricultural and materials industries. Genome sequencing has revealed that these industries currently rely on only a fraction of the number of natural products that exist in nature. Based on the impact that known natural products...

Keyword:

Biosynthesis, Streptomyces, Natural Products, Mass Spectrometry, Cell-Free Protein Synthesis, and Secondary Metabolism

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Anthony Whitney Goering

Owner:

Scholarly Digital Publishing

Date Uploaded:

03/13/2018

Date Modified:

01/28/2019

Date Created:

2017-01-01

Resource Type:

Dissertation
Interrogation of the Proteoform Landscape of Immune Activation after Organ Transplantation: Translational Top-Down Proteomics for Next-Generation Diagnostics and Personalized Medicine

Description:

What follows is a strictly post-genomic dissertation. Over the past five years, I have strived to leave the nucleus behind, and even the endoplasmic reticulum and golgi apparatus. The human genome was sequenced over 15 years before the submission of this document, and the world changed somewhat less than anticipated—besides...

Keyword:

Top-Down Proteomics, Proteomics, Transplantation, Immunology, Mass Spectrometry, and Proteoforms

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Tinothy Toby

Owner:

Scholarly Digital Publishing

Date Uploaded:

01/25/2019

Date Modified:

01/25/2019

Date Created:

2017-01-01

Resource Type:

Dissertation

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High-Throughput Discovery of Natural Products Using Hundreds of Bacterial Genomes and a Correlative Method

Interrogation of the Proteoform Landscape of Immune Activation after Organ Transplantation: Translational Top-Down Proteomics for Next-Generation Diagnostics and Personalized Medicine

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