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Studies of the Epigenetic Regulator NSD2 by Targeted and Quantitative Mass Spectrometry

Description:

Epigenetics is the study of chromatin-based events that regulate gene expression without the change of DNA sequence, including DNA methylation, histone modification and chromatin remodeling. Epigenetic regulators are encoded to modify chromatin in a highly regulated and dynamic manner. A growing number of studies have suggested the dysregulation of epigenetic...

Keyword:

Biological sciences, Histone methylation, Proteomics, Mass spectrometry, Protein interaction, and Epigenetics

Subject:

Analytical chemistry, Molecular biology, and Biochemistry

Creator:

Huang, Xiaoxiao

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_686355 and http://dissertations.umi.com/northwestern:14838
High-Throughput Development of Glycosyltransferase Assays Using SAMDI-MS

Description:

More than half of proteins in humans are modified with carbohydrates in a process called glycosylation, yet this process remains poorly understood even though approximately 1% of the expressed human genome encodes biosynthetic machinery for glycosylation. Unlike genomics and proteomics where high throughput tools are now routinely used to generate...

Keyword:

SAMDI, High-throughput protein synthesis, glycosylation, self-assembled monolayers, glycosyltransferase, and Mass spectrometry

Subject:

Bioengineering, Analytical chemistry, and Biochemistry

Creator:

Techner, Jose-Marc

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14598 and etdadmin_upload_661107

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Studies of the Epigenetic Regulator NSD2 by Targeted and Quantitative Mass Spectrometry

High-Throughput Development of Glycosyltransferase Assays Using SAMDI-MS

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