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Description:: Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a fuel source. A bootstrap analysis for genes with deviant...
Keyword:: Heart Failure, Glucose, Cardiomyopathy, Drosophila, Metabolism, and Mitochondria
Subject:: Molecular biology, Gender studies, and Cellular biology
Creator:: Fischer, Julie Anne
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16326 and etdadmin_upload_941216

Description:: Mitochondrial complex I is the primary entry point for electrons into the mitochondrial electron transport chain that is composed of 45 individual protein subunits that are encoded in both the nuclear and mitochondrial genomes. Mitochondrial complex I sits at an important nexus in the essential bioenergetic, biosynthetic, and signaling functions...
Keyword:: NDI1, NDUFS2, NDUFS4, Mitochondria, Leigh Syndrome, and Metabolism
Subject:: Biology, Aging, and Neurosciences
Creator:: McElroy, Gregory Scott
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_746970 and http://dissertations.umi.com/northwestern:15152

Description:: The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...
Keyword:: Inflammation, Hexokinase, Macrophage, Subcellular localization, Metabolism, and Mitochondria
Subject:: Biology
Creator:: De Jesus, Adam
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_773389 and http://dissertations.umi.com/northwestern:15348

Description:: Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels to support cancer cells is not fully understood. To address this, we conducted a metabolism-focused CRISPR/Cas9 genetic screen and uncovered that loss of genes encoding...
Keyword:: Reactive oxygen species, Cancer, Mitochondria, and Metabolism
Subject:: Biology, Health sciences, and Medicine
Creator:: Kong, Hyewon
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_775698 and http://dissertations.umi.com/northwestern:15362

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