Limit your search
Search Constraints
Filtering by:
Keyword
Metabolism
Remove constraint Keyword: Metabolism
Resource type
Dissertation
Remove constraint Resource type: Dissertation
1 - 8 of 8
Number of results to display per page
Search Results
-
- Description:
- Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a fuel source. A bootstrap analysis for genes with deviant...
- Keyword:
- Heart Failure, Glucose, Cardiomyopathy, Drosophila, Metabolism, and Mitochondria
- Subject:
- Molecular biology, Gender studies, and Cellular biology
- Creator:
- Fischer, Julie Anne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16326 and etdadmin_upload_941216
-
- Description:
- Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system tumor, characterized by resistance to therapeutic intervention, inevitable recurrence, and ultimately patient death. The dismal prognosis is due in part to underlying molecular factors that promote an intratumoral cellular state heterogeneity and protect tumor cells from cell death pathways....
- Keyword:
- Ferroptosis, Glioblastoma, Cancer, Stemness, Metabolism, and IDH1
- Subject:
- Molecular biology, Medicine, and Neurosciences
- Creator:
- Murnan, Kevin Michael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15885 and etdadmin_upload_865864
-
- Description:
- Mitochondrial complex I is the primary entry point for electrons into the mitochondrial electron transport chain that is composed of 45 individual protein subunits that are encoded in both the nuclear and mitochondrial genomes. Mitochondrial complex I sits at an important nexus in the essential bioenergetic, biosynthetic, and signaling functions...
- Keyword:
- NDI1, NDUFS2, NDUFS4, Mitochondria, Leigh Syndrome, and Metabolism
- Subject:
- Biology, Aging, and Neurosciences
- Creator:
- McElroy, Gregory Scott
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_746970 and http://dissertations.umi.com/northwestern:15152
-
- Description:
- Iron is an essential nutrient and is critical for cellular growth and metabolism. Here, we delineate a novel mechanism by which iron alters amino acid homeostasis and mTOR activity by remodeling the cellular epigenetic landscape. We find that iron deficiency inactivates Jumonji-C domain containing histone-demethylases, resulting in histone hyper-methylation and...
- Keyword:
- Iron, Epigenetics, Mitophagy, Metabolism, and mTOR
- Subject:
- Cellular biology
- Creator:
- Shapiro, Jason Solomon
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15209 and etdadmin_upload_759499
-
- Description:
- The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...
- Keyword:
- Inflammation, Hexokinase, Macrophage, Subcellular localization, Metabolism, and Mitochondria
- Subject:
- Biology
- Creator:
- De Jesus, Adam
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_773389 and http://dissertations.umi.com/northwestern:15348
-
- Description:
- Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels to support cancer cells is not fully understood. To address this, we conducted a metabolism-focused CRISPR/Cas9 genetic screen and uncovered that loss of genes encoding...
- Keyword:
- Reactive oxygen species, Cancer, Mitochondria, and Metabolism
- Subject:
- Biology, Health sciences, and Medicine
- Creator:
- Kong, Hyewon
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_775698 and http://dissertations.umi.com/northwestern:15362
-
- Description:
- Transcription is tightly regulated to ensure genes are appropriately expressed both temporally and spatially. This tight regulation governs various processes within the cell, such as differentiation and cell identity, cellular maintenance, and dynamic responses to external signals. Transcription factors (TFs) coordinate these various gene programs and in particular, are key...
- Keyword:
- Repressor, NAFLD, PPAR alpha, BCL6, Transcription, and Metabolism
- Subject:
- Molecular biology and Biology
- Creator:
- Sommars, Meredith Anne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_663025 and http://dissertations.umi.com/northwestern:14672
-
- Description:
- Organismal development depends upon countless cell decisions to adopt particular fates at the appropriate time and place. These decisions are executed by systems of biochemical reactions called regulatory networks. Elucidating the general principles underlying the structure and function of these networks is vital to understanding all developmental processes, as well...
- Keyword:
- Development, Quantitative Biology, Cell Decisions, Mosaic Analysis, Drosophila, and Metabolism
- Subject:
- Chemical engineering and Developmental biology
- Creator:
- Bernasek, Sebastian Michal
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_663067 and http://dissertations.umi.com/northwestern:14676