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Investigating MTCH2 as a genetic modifier of cardiomyopathy

Description:

Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a fuel source. A bootstrap analysis for genes with deviant...

Keyword:

Heart Failure, Glucose, Cardiomyopathy, Drosophila, Metabolism, and Mitochondria

Subject:

Molecular biology, Gender studies, and Cellular biology

Creator:

Fischer, Julie Anne

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16326 and etdadmin_upload_941216
Iron Regulates Cellular Metabolism and Mitophagy Through Epigenetic Control of mTORC1

Description:

Iron is an essential nutrient and is critical for cellular growth and metabolism. Here, we delineate a novel mechanism by which iron alters amino acid homeostasis and mTOR activity by remodeling the cellular epigenetic landscape. We find that iron deficiency inactivates Jumonji-C domain containing histone-demethylases, resulting in histone hyper-methylation and...

Keyword:

Iron, Epigenetics, Mitophagy, Metabolism, and mTOR

Subject:

Cellular biology

Creator:

Shapiro, Jason Solomon

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15209 and etdadmin_upload_759499

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Investigating MTCH2 as a genetic modifier of cardiomyopathy

Iron Regulates Cellular Metabolism and Mitophagy Through Epigenetic Control of mTORC1

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