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Type

Work3

Resource type

Dissertation3

Creator

Fischer, Julie Anne1
Murnan, Kevin Michael1
Sommars, Meredith Anne1

Keyword

Metabolism[remove]3
BCL61
Cancer1
Cardiomyopathy1
Drosophila1
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Subject

Molecular biology[remove]3
Biology1
Cellular biology1
Gender studies1
Medicine1
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Language

en3

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Filtering by: Keyword Metabolism Remove constraint Keyword: Metabolism Subject Molecular biology Remove constraint Subject: Molecular biology

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Investigating MTCH2 as a genetic modifier of cardiomyopathy

Description:

Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a fuel source. A bootstrap analysis for genes with deviant...

Keyword:

Heart Failure, Glucose, Cardiomyopathy, Drosophila, Metabolism, and Mitochondria

Subject:

Molecular biology, Gender studies, and Cellular biology

Creator:

Fischer, Julie Anne

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16326 and etdadmin_upload_941216
Defining and Therapeutically Targeting IDH1-WT Oncogenicity in GBM

Description:

Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system tumor, characterized by resistance to therapeutic intervention, inevitable recurrence, and ultimately patient death. The dismal prognosis is due in part to underlying molecular factors that promote an intratumoral cellular state heterogeneity and protect tumor cells from cell death pathways....

Keyword:

Ferroptosis, Glioblastoma, Cancer, Stemness, Metabolism, and IDH1

Subject:

Molecular biology, Medicine, and Neurosciences

Creator:

Murnan, Kevin Michael

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15885 and etdadmin_upload_865864
Genomic Coordination of Hepatic Lipid Metabolism and Fasting by BCL6

Description:

Transcription is tightly regulated to ensure genes are appropriately expressed both temporally and spatially. This tight regulation governs various processes within the cell, such as differentiation and cell identity, cellular maintenance, and dynamic responses to external signals. Transcription factors (TFs) coordinate these various gene programs and in particular, are key...

Keyword:

Repressor, NAFLD, PPAR alpha, BCL6, Transcription, and Metabolism

Subject:

Molecular biology and Biology

Creator:

Sommars, Meredith Anne

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_663025 and http://dissertations.umi.com/northwestern:14672

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