Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...
Keyword:: microRNA, Compositional Data Analysis, TDP-43 Proteinopathy, FUS Proteinopathy, RNA-Seq, and Mitochondria
Subject:: Molecular biology, Bioinformatics, and Neurosciences
Creator:: McGee, Warren A
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14675 and etdadmin_upload_663037

Description:: Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...
Keyword:: iPSC, Interorganelle contacts, GBA, Lysosome, Mitochondria, and Parkinson's disease
Subject:: Molecular biology, Cellular biology, and Neurosciences
Creator:: Kim, Soojin
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_825288 and http://dissertations.umi.com/northwestern:15606

Description:: Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a fuel source. A bootstrap analysis for genes with deviant...
Keyword:: Heart Failure, Glucose, Cardiomyopathy, Drosophila, Metabolism, and Mitochondria
Subject:: Molecular biology, Gender studies, and Cellular biology
Creator:: Fischer, Julie Anne
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16326 and etdadmin_upload_941216

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