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Description:: Latent membrane protein 2A (LMP2A) and LMP2B are viral proteins expressed during Epstein-Barr virus (EBV) latency in EBV-infected B cells both in cell culture and in vivo. Although Lyn has been shown to be important in mediating LMP2A signaling, it is still unclear if Lyn is used preferentially or if...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Mark Rovedo
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/18/2018
Date Modified:: 09/18/2018
Date Created:: 2008-09-03
Resource Type:: Dissertation

Description:: Epstein-Barr virus (EBV) is a human gamma-herpesvirus that primarily infects B cells and epithelial cells. While the glycoproteins required for entry into these two cell types differ, the gH/gL glycoprotein complex is essential for entry into both epithelial and B cells. Analysis of gH protein sequences from three gamma-herpesviruses: EBV,...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Jasmina Omerovic
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/05/2018
Date Modified:: 06/05/2018
Date Created:: 2007-05-09
Resource Type:: Dissertation

Description:: HspB2 was discovered as a chaperone of muscular dystrophy protein kinase (DMPK) and originally named, DMPK binding protein (MKBP) and presently called HspB2. Functionally, MKBP binds to DMPK and stabilizes its kinase activity, thereby accelerating the progression of muscular dystrophy. Although other binding partners of HspB2 have been found, the...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Shayna Oshita
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/27/2018
Date Modified:: 08/27/2018
Date Created:: 2007-08-28
Resource Type:: Dissertation

Description:: The response to reduced levels of oxygen (hypoxia) is essential for embryonic development by promoting the proper formation of vascular networks. Conversely, hypoxia also promotes the development of pathophysiological processes such as pulmonary hypertension and cancer. The main mediator of responses to hypoxia within the cell is the transcription factor...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Eric Bell
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/01/2018
Date Modified:: 08/01/2018
Date Created:: 07-27-2007
Resource Type:: Dissertation

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