Alzheimer's disease (AD) is a progressive amnestic dementia typified by the pathological self-association of the microtubule-associated tau protein into neurofibrillary tangles (NFTs). Important to NFT formation are numerous modifications of tau, including phosphorylation, truncation, and conformational changes. In addition, AD-associated inflammation promotes the formation of peroxynitrite (ONOO-), a potent nitrating...