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Genomic Coordination of Hepatic Lipid Metabolism and Fasting by BCL6

Description:

Transcription is tightly regulated to ensure genes are appropriately expressed both temporally and spatially. This tight regulation governs various processes within the cell, such as differentiation and cell identity, cellular maintenance, and dynamic responses to external signals. Transcription factors (TFs) coordinate these various gene programs and in particular, are key...

Keyword:

Repressor, NAFLD, PPAR alpha, BCL6, Transcription, and Metabolism

Subject:

Molecular biology and Biology

Creator:

Sommars, Meredith Anne

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_663025 and http://dissertations.umi.com/northwestern:14672
Characterization of HKDC1 and Involvement in NAFLD Development

Description:

The literature has established glucokinase (GCK) to be the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. We have recently proposed Hexokinase Domain Containing-1 (HKDC1) to be a novel 5th HK with expression in the liver. Here, we reveal HKDC1...

Keyword:

Hexokinase, NAFLD, Liver Metabolism, and HKDC1

Subject:

Molecular biology, Biology, and Biochemistry

Creator:

Pusec, Carolina

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14450 and etdadmin_upload_626205

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Genomic Coordination of Hepatic Lipid Metabolism and Fasting by BCL6

Characterization of HKDC1 and Involvement in NAFLD Development

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