ABSTRACT Genome Mining in Actinobacteria via a Hybrid-Omics Discovery Platform James Hudson Tryon Natural products isolated from Actinobacteria are a vital source of medicines, agrochemicals, and commodity chemicals. The traditional, activity-driven fractionation pipelines that provided access to many of these natural products have delivered diminishing returns in recent decades. However,...
Natural products provide a renewable resource of novel chemical structures with relevance to the pharmaceutical, agricultural and materials industries. Genome sequencing has revealed that these industries currently rely on only a fraction of the number of natural products that exist in nature. Based on the impact that known natural products...