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The biosynthesis, regulation, and transport of methanobactins

Description:

Methanobactins (Mbns) are a growing family of ribosomally produced, post-translationally modified natural products that exhibit a high affinity for copper. These compounds were initially identified in methanotrophic bacteria, which oxidize methane to methanol as their sole source of carbon. One of the key enzymes in this metabolic pathway, particulate methane...

Keyword:

Methanobactin, Biosynthesis, Copper homeostasis, Methanotrophy, Chalkophores, and Natural products

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Grace Eileen Kenney

Owner:

Scholarly Digital Publishing

Date Uploaded:

01/10/2019

Date Modified:

01/29/2019

Date Created:

2017-01-01

Resource Type:

Dissertation
Discovering Natural Products from Aspergillus nidulans through Metabolomics and HDAC Inhibition

Description:

Fungi have an immense untapped store of natural products, small molecules that can often be repurposed as pharmaceuticals. The genes that encode secondary metabolic machinery are often genomically co-localized into biosynthetic gene clusters. Because of the immense energetic costs that goes into producing the biosynthetic pathway and its products, strict...

Keyword:

LC-MS, NRPS, Natural products, Aspergillus nidulans, metabolomics, and HDAC

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Matthew Thomas Henke

Owner:

Scholarly Digital Publishing

Date Uploaded:

02/20/2018

Date Modified:

02/20/2018

Date Created:

2016-01-01

Resource Type:

Dissertation

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The biosynthesis, regulation, and transport of methanobactins

Discovering Natural Products from Aspergillus nidulans through Metabolomics and HDAC Inhibition

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