The brains of humans and animals have the amazing capability of extracting abstract relationships between external stimuli efficiently. Knowing such regularities helps us compute and react to novel information flexibly without prior experience. The olfactory system is no exception. Animals need to infer commonalities across different odors sharing similar meaning,...
Mounting evidence indicates that known schizophrenia susceptibility genes regulate dendritic spines supports the model that perturbations in the molecular network underlying spine plasticity are crucially involved in the pathogenesis of schizophrenia. The Rac1- and RhoA-guanine nucleotide exchange factor (GEF) kalirin is critical for spine morphogenesis on cortical pyramidal neurons, and...
The form and function of neural circuits are shaped by experience during critical periods of development. Recently, our lab discovered an important outcome of critical period plasticity in the visual system, namely, binocular matching of orientation preference, whereby initially randomly aligned orientation preferences become matched in individual cells. Following this...
The over-a-decade quantitative study of the flexion synergy has provided concrete evidence that the stereotypical movement coupling of shoulder abduction with elbow flexion and wrist/finger flexion (i.e. flexion synergy) significantly affects the ability to perform functional upper extremity movements that are essential for activities of daily living (e.g. reach-to-grasp an...
Kainate receptors (KARs) are expressed throughout the central and peripheral nervous systems. One of three subfamilies of ionotropic glutamate receptors, KARs are localized both pre- and post-synaptically and exert important modulatory control over neural circuits. This modulatory role in circuit function makes them a potential actor in wide variety of...
Fetal alcohol spectrum disorder (FASD), the result of fetal alcohol exposure (FAE), affects 2-11% of children worldwide with no treatments in sight. In my thesis work, I aimed to identify underlying biological mechanisms of the FAE-induced hippocampus-based cognitive deficits that would lead to identify potential treatment targets to reverse the...