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Filtering by: Keyword Parkinson's Disease Keyword deep brain stimulation Keyword basal ganglia Keyword globus pallidus

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1. Regulation of autonomous pacemaking and high frequency firing in the basal ganglia

Description:: Following dopaminergic denervation in Parkinson's Disease, firing patterns in several basal ganglia neuron populations are pathologically altered. In the globus pallidus (GP), this manifests as a loss of autonomous, rhythmic, high-frequency pacemaking and an appearance of correlated, oscillatory bursting. This oscillatory bursting is best disrupted through high-frequency stimulation of affected...
Keyword:: Parkinson's Disease, sodium channels, globus pallidus, pacemaking, deep brain stimulation, and basal ganglia
Subject:: Neuroscience Institute Graduate Program
Creator:: Jeff Mercer
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/10/2018
Date Modified:: 05/10/2018
Date Created:: 2006-12-19
Resource Type:: Dissertation