Northwestern University

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Filtering by: Keyword Parkinson's disease Keyword GBA

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Misregulation of Mitochondria-Lysosome Contact Sites in GBA-linked Parkinson’s Disease

Description:

Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...

Keyword:

iPSC, Interorganelle contacts, GBA, Lysosome, Mitochondria, and Parkinson's disease

Subject:

Molecular biology, Cellular biology, and Neurosciences

Creator:

Kim, Soojin

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_825288 and http://dissertations.umi.com/northwestern:15606