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fMRI Correlates of Speech and Voice Impairment in Parkinson’s Disease

Description:

Approximately 80-90% of individuals with Parkinson’s disease (PD) develop motor speech impairments, predominantly in the form of voice dysfunction. It is known that the motor symptoms of PD arise from degeneration of the dopamine producing neurons in the substantia nigra and dysregulation of basal ganglia motor pathways. It is also...

Keyword:

neuroimaging, dysarthria, fMRI, basal ganglia, hypophonia, and Parkinson's disease

Subject:

Neurosciences and Communication

Creator:

Manes, Jordan Leigh

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_759611 and http://dissertations.umi.com/northwestern:15211
Autonomous Subthalamic Nucleus Activity in a Mouse Model of Parkinson's Disease: Mechanisms of Disruption and Consequences of Its Restoration

Description:

Parkinson's disease (PD) is a movement disorder that arises following the degeneration of dopamine-producing neurons of the substantia nigra pars compacta (SNc). Patients experience a host of limiting motor symptoms such as rigidity, tremor, and a paucity of controlled movement generation. These symptoms often correspond with a predominance of abnormally...

Keyword:

KATP channel, chemogenetics, basal ganglia, subthalamic nucleus, Parkinson's disease, and autonomous activity

Subject:

Interdepartmental Neuroscience Program (NUIN)

Creator:

Eileen McIver

Owner:

Scholarly Digital Publishing

Date Uploaded:

10/21/2019

Date Modified:

10/21/2019

Date Created:

2018-01-01

Resource Type:

Dissertation

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fMRI Correlates of Speech and Voice Impairment in Parkinson’s Disease

Autonomous Subthalamic Nucleus Activity in a Mouse Model of Parkinson's Disease: Mechanisms of Disruption and Consequences of Its Restoration

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