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Description:: Parkinson’s disease (PD) is the second most common neurodegenerative disorder, causing devastating disabilities in both motor and non-motor domains following the degeneration of dopamine (DA) producing neurons of the substantia nigra pars compacta (SNc). Current treatments are highly limited in efficacy, and no established treatments currently exist to alter disease...
Keyword:: molecular subtypes, dopamine, and Parkinson's disease
Subject:: Neurosciences
Creator:: Gaertner, Zachary Aaron
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_983728 and http://dissertations.umi.com/northwestern:16518

Description:: Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...
Keyword:: iPSC, Interorganelle contacts, GBA, Lysosome, Mitochondria, and Parkinson's disease
Subject:: Molecular biology, Cellular biology, and Neurosciences
Creator:: Kim, Soojin
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_825288 and http://dissertations.umi.com/northwestern:15606

Description:: Approximately 80-90% of individuals with Parkinson’s disease (PD) develop motor speech impairments, predominantly in the form of voice dysfunction. It is known that the motor symptoms of PD arise from degeneration of the dopamine producing neurons in the substantia nigra and dysregulation of basal ganglia motor pathways. It is also...
Keyword:: neuroimaging, dysarthria, fMRI, basal ganglia, hypophonia, and Parkinson's disease
Subject:: Neurosciences and Communication
Creator:: Manes, Jordan Leigh
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_759611 and http://dissertations.umi.com/northwestern:15211

Description:: Parkinson's disease (PD) is a movement disorder that arises following the degeneration of dopamine-producing neurons of the substantia nigra pars compacta (SNc). Patients experience a host of limiting motor symptoms such as rigidity, tremor, and a paucity of controlled movement generation. These symptoms often correspond with a predominance of abnormally...
Keyword:: KATP channel, chemogenetics, basal ganglia, subthalamic nucleus, Parkinson's disease, and autonomous activity
Subject:: Interdepartmental Neuroscience Program (NUIN)
Creator:: Eileen McIver
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/21/2019
Date Modified:: 10/21/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

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