Northwestern University

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Autophagy Dysfunction in Parkinson’s Disease and Related Synucleinopathies

Description:

Genetic studies have found variants in the protein-degrading autophagy-lysosomal pathway (ALP) to be among the most common risk factors for developing Parkinson’s disease (PD). Macroautophagy (MA) is the arm of this pathway which delivers cytosolic components to lysosomes for degradation and is essential for neuronal health. The defining pathological protein...

Keyword:

ykt6, synuclein, Parkinson disease, SNARE, autophagy, and farnesyltransferase inhibitor

Subject:

Molecular biology, Biochemistry, and Neurosciences

Creator:

Pitcairn, Caleb

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

05/31/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16447 and etdadmin_upload_970290