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Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells

Description:

The hormone prolactin (PRL) contributes to breast cancer pathogenesis through various signaling pathways, one of the most notable being the JAK2/signal transducer and activator of transcription 5 (STAT5) pathway. PRL-induced activation of the transcription factor STAT5 results in the upregulation of numerous genes implicated in breast cancer pathogenesis. However, the...

Keyword:

Transcription factor, HMGN, Histone H1, Chromatin, STAT5, and Prolactin

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Suzanne Marie Schauwecker

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/18/2018

Date Modified:

04/18/2018

Date Created:

2017-01-01

Resource Type:

Dissertation
Phosphoregulation of NEK3 Kinase in the Pathogenesis of Human Breast Carcinoma

Description:

The polypeptide hormone prolactin (PRL) is increasingly recognized as contributing to the development and progression of human breast cancer. This is supported by epidemiologic studies that found women with high levels of serum PRL are at an increased risk for developing breast cancer. Activation of the prolactin receptor (PRLR) by...

Keyword:

Focal Adhesion, Prolactin, Breast Cancer, Cell Migration, and Phosphorylation

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Katherine Marie Schulhaus

Owner:

Scholarly Digital Publishing

Date Uploaded:

03/13/2018

Date Modified:

03/13/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells

Phosphoregulation of NEK3 Kinase in the Pathogenesis of Human Breast Carcinoma

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