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Overcoming Temozolomide Resistance in Glioblastoma Multiforme with MGMT-Targeting Spherical Nucleic Acids

Description:

Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system malignancy. Due to the aggressive nature of these tumors and our inability to adequately treat them, only 3-5% of patients survive longer than 3 years post-diagnosis. The standard of care for newly diagnosed GBM is surgical resection followed by...

Keyword:

siRNA, Ribozyme, Glioblastoma, Spherical nucleic acids, Gold nanoparticles, and MGMT

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Timothy L. Sita

Owner:

Scholarly Digital Publishing

Date Uploaded:

03/12/2018

Date Modified:

03/12/2018

Date Created:

2017-01-01

Resource Type:

Dissertation