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Advancing the Delivery and Therapeutic Potential of Biologics with Spherical Nucleic Acids

Description:

The translation of proteins as effective intracellular drug candidates is limited by the challenge of cellular entry and their vulnerability to degradation. To advance their therapeutic potential, cell-impermeable proteins can be readily transformed into protein spherical nucleic acids (ProSNAs) or encapsulated into liposomal spherical nucleic acids (L-SNAs), structures defined by...

Keyword:

Intracellular Delivery, Enzyme, Spherical Nucleic Acid, Cancer Vaccine, Biologic, and Blood-Brain Barrier

Subject:

Chemistry

Creator:

Kusmierz, Caroline Danielle

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15666 and etdadmin_upload_837502
Liposomal Spherical Nucleic Acid Trafficking In Vivo

Description:

Spherical Nucleic Acids (SNAs) are unique class of nanomaterial characterized by a dense nucleic acid shell conjugated to a nanoparticle core. This radial orientation of oligonucleotides and architecture distinguishes SNAs from the components from which they are comprised. Specifically, unique chemical and biological properties emerge that are not observed with...

Keyword:

Spherical Nucleic Acid, Nanoparticle, Immune system, Toll-like receptors, and Biodistribution

Subject:

Nanotechnology, Chemistry, and Immunology

Creator:

Ferrer, Jennifer R

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14715 and etdadmin_upload_668701

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Advancing the Delivery and Therapeutic Potential of Biologics with Spherical Nucleic Acids

Liposomal Spherical Nucleic Acid Trafficking In Vivo

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