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Strategies for the Design and Field Deployment of Cell-Free Biosensors

Description:

Three in ten people worldwide lack access to a safely managed source of drinking water, with one in ten lacking access to a drinking water service altogether. This is projected to worsen in the coming years as climate change, infrastructure degradation, and poor governance work to further increase global water...

Keyword:

Diagnostic, Deployment, Biosensor, Water, Synthetic Biology, and RNA

Subject:

Bioengineering

Creator:

Thavarajah, Walter

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

09/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_920589 and http://dissertations.umi.com/northwestern:16173
Source Data for "Point-of-use detection of environmental fluoride via a cell-free riboswitch-based biosensor."

Description:

Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for fluoride, a major groundwater contaminant of global concern. The sensor consists of a cell-free system containing a DNA template that...

Keyword:

Diagnostic, Fluoride, Riboswitch, Cell-Free, and Synthetic Biology

Subject:

Synthetic Biology and Diagnostics

Creator:

Nancy Kelley-Loughnane, Matthew S. Verosloff, Michael C. Jewett, Walter Thavarajah, Julius B. Lucks, and Adam D. Silverman

Contributor:

This work was supported by the Air Force Research Laboratory Center of Excellence for Advanced Bioprogrammable Nanomaterials (C-ABN) Grant FA8650-15-2-5518 (to M.C.J. and J.B.L), the David and Lucile Packard Foundation (to M.C.J.), an NSF CAREER Award (1452441 to J.B.L.), and the Camille Dreyfus Teacher-Scholar Program (to M.C.J. and J.B.L.). A.D.S. was supported in part by the National Institutes of Health Training Grant (T32GM008449) through Northwestern University’s Biotechnology Training Program.

Owner:

Julius Beau Lucks

Language:

English

Date Uploaded:

06/18/2019

Date Modified:

01/08/2020

Date Created:

2019-06-04

Resource Type:

Dataset

Alternate Identifier:

https://doi.org/10.21985/N2RJ64

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Strategies for the Design and Field Deployment of Cell-Free Biosensors

Source Data for "Point-of-use detection of environmental fluoride via a cell-free riboswitch-based biosensor."

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