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- The development of the deconstruction approach was supported by the National Science Foundation through the support of the SynBAS NRT program (2021900).1
- This work was supported by the Air Force Research Laboratory Center of Excellence for Advanced Bioprogrammable Nanomaterials (C-ABN) Grant FA8650-15-2-5518 (to M.C.J. and J.B.L), the David and Lucile Packard Foundation (to M.C.J.), an NSF CAREER Award (1452441 to J.B.L.), and the Camille Dreyfus Teacher-Scholar Program (to M.C.J. and J.B.L.). A.D.S. was supported in part by the National Institutes of Health Training Grant (T32GM008449) through Northwestern University’s Biotechnology Training Program. 1
- Synthetic Biology[remove]10
- Biosensor3
- Diagnostic2
- Fluoride2
- RNA2
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- Description:
- These supplementary materials are in support of the manuscript "Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists," in which we describe a framework for synthetic biology training that deconstructs biotechnologies across scales—molecular, circuit/network, cell/cell-free systems, biological communities, and societal—giving students a holistic toolkit to integrate cross-disciplinary...
- Keyword:
- Synthetic Biology and Education
- Creator:
- Northwestern Center for Synthetic Biology, Ashty S. Karim, and Julius B. Lucks
- Contributor:
- The development of the deconstruction approach was supported by the National Science Foundation through the support of the SynBAS NRT program (2021900).
- Owner:
- Ashty Stephen Karim
- Date Uploaded:
- 03/11/2024
- Date Modified:
- 03/11/2024
-
- Description:
- Three in ten people worldwide lack access to a safely managed source of drinking water, with one in ten lacking access to a drinking water service altogether. This is projected to worsen in the coming years as climate change, infrastructure degradation, and poor governance work to further increase global water...
- Keyword:
- Diagnostic, Deployment, Biosensor, Water, Synthetic Biology, and RNA
- Subject:
- Bioengineering
- Creator:
- Thavarajah, Walter
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_920589 and http://dissertations.umi.com/northwestern:16173
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- Description:
- Geogenic fluoride contaminates the water of tens of millions of people. However, many are unaware of the fluoride content due in part to shortcomings of detection methods. Biosensor tests are a relatively new approach to water quality testing that address many of these shortcomings but have never been tested by...
- Keyword:
- Synthetic Biology, Fluoride, WASH, Biosensor, and DIagnostic
- Creator:
- Awuor, Diana Ross, Lucks, Julius B, Owuor, Patrick Mbullo, Aggarwal, Rahul, Thavarajah, Walter, Kiprotich, Karlmax, and Young, Sera L
- Owner:
- Walter Math Thavarajah
- Publisher:
- Northwestern University
- Language:
- English
- Date Uploaded:
- 07/07/2022
- Date Modified:
- 07/08/2022
- Date Created:
- 2022
- Resource Type:
- Dataset
-
- Description:
- Ensuring adequate water quality is essential for human health and for effective allocation of resources in agriculture, energy, and manufacturing. However, the current state-of-the-art for water quality testing requires expensive equipment and technical expertise to analyze samples and takes days to obtain results from off-site labs, making it inaccessible to...
- Keyword:
- Synthetic Biology, Nucleic Acid Circuit, In Vitro Transcription, Biosensor, Transcription Factor, and RNA
- Subject:
- Bioengineering and Molecular biology
- Creator:
- Jung, Jaeyoung Kirsten
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15989 and etdadmin_upload_893092
-
- Description:
- The Escherichia coli ribosome is a molecular machine capable of sequence-defined polymerization of -amino acids into proteins, a feat unmatched by any other current synthetic catalyst. It is complex in its structure, comprised of 3 RNA parts (the 5S, 16S, and 23S ribosomal RNAs) and 54 ribosomal proteins (r-proteins). Efforts...
- Keyword:
- Synthetic Biology, RNA Design, and Ribosome Engineering
- Subject:
- Bioengineering, Bioinformatics, and Chemical engineering
- Creator:
- Kim, Do Soon
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/06/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_831423 and http://dissertations.umi.com/northwestern:15634
-
- Description:
- Regulatory RNAs are found throughout nature controlling critical cellular processes and enabling cells to sense and respond to their environment. In order to provide genetic regulation, these RNAs can selectively bind to target molecules, proteins, and invading pathogens, all while modulating gene expression on both the transcriptional and translational level....
- Keyword:
- Synthetic Biology, Regulatory RNA , Diagnostics, Transcription Regulation, and Intrinsic Termination
- Subject:
- Molecular biology
- Creator:
- Verosloff, Matthew Stuart
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15425 and etdadmin_upload_782101
-
- Description:
- The fields of metabolic engineering and synthetic biology have emerged in recent years with the heavily overlapping goals of sustainable bioproduction of chemical goods and predictable and precise engineering of biological function.1 However, efforts to reach commercially relevant titers have stalled.2 Many challenges arise during optimization of each production platform,...
- Keyword:
- Synthetic Biology, Limonene, Non-growth Metabolism, and Metabolic Engineering
- Subject:
- Chemical engineering
- Creator:
- Bothfeld, William Henry
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_621404 and http://dissertations.umi.com/northwestern:14420
-
- Description:
- Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for fluoride, a major groundwater contaminant of global concern. The sensor consists of a cell-free system containing a DNA template that...
- Keyword:
- Diagnostic, Fluoride, Riboswitch, Cell-Free, and Synthetic Biology
- Subject:
- Synthetic Biology and Diagnostics
- Creator:
- Nancy Kelley-Loughnane, Matthew S. Verosloff, Michael C. Jewett, Walter Thavarajah, Julius B. Lucks, and Adam D. Silverman
- Contributor:
- This work was supported by the Air Force Research Laboratory Center of Excellence for Advanced Bioprogrammable Nanomaterials (C-ABN) Grant FA8650-15-2-5518 (to M.C.J. and J.B.L), the David and Lucile Packard Foundation (to M.C.J.), an NSF CAREER Award (1452441 to J.B.L.), and the Camille Dreyfus Teacher-Scholar Program (to M.C.J. and J.B.L.). A.D.S. was supported in part by the National Institutes of Health Training Grant (T32GM008449) through Northwestern University’s Biotechnology Training Program.
- Owner:
- Julius Beau Lucks
- Language:
- English
- Date Uploaded:
- 06/18/2019
- Date Modified:
- 01/08/2020
- Date Created:
- 2019-06-04
- Resource Type:
- Dataset
- Alternate Identifier:
- https://doi.org/10.21985/N2RJ64
-
- Description:
- The Escherichia coli ribosome is a 2.4 MDa molecular machine that consists of a large subunit and a small subunit, and is the key catalyst in gene expression, responsible for synthesizing proteins from amino acids in a sequence-defined fashion with impressive speed and accuracy. Expanding the repertoire of ribosome substrates...
- Keyword:
- Synthetic Biology, Ribosome engineering, and Orthogonal translation
- Subject:
- Chemical and Biological Engineering
- Creator:
- Erik Daniel Carlson
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 10/09/2018
- Date Modified:
- 10/09/2018
- Date Created:
- 2017-01-01
- Resource Type:
- Dissertation
-
- Description:
- A disconnect exists between the behavior of transcriptional and genetic regulation in bacterial systems when comparing phenotypic patterns and dynamics of a population to those observed at the single cell level. In this thesis, we developed a number of tools and assays to better understand, overcome, and predict the challenges...
- Keyword:
- Synthetic Biology, Bacterial Signalling, Genomic Regulation, Conjugation, and Genomic Heterogeneity
- Subject:
- Interdepartmental Biological Sciences (IBiS) Graduate Program
- Creator:
- Andrew Hilz Scarpelli
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 02/20/2018
- Date Modified:
- 02/20/2018
- Date Created:
- 2016-01-01
- Resource Type:
- Dissertation