Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Pollution-intensive industrial manufacturing processes threaten the health of ecosystems and societies through toxic waste streams and energy intensive processes that lead to greenhouse gas emissions. Biological systems present more sustainable routes to many useful industrial chemicals by using enzymes at low temperatures, but the time and effort required to optimized...
Keyword:: Cell-free, Synthetic biology, Metabolic engineering, and Biomanufacturing
Subject:: Molecular biology and Chemical engineering
Creator:: Rasor, Blake
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_994770 and http://dissertations.umi.com/northwestern:16630

Description:: Cellular translation is responsible for the synthesis of proteins, a highly diverse class of macromolecules that form the basis of biological function. In Escherichia coli, harnessing and engineering of the biomolecular components of translation, such as ribosomes, transfer RNAs (tRNAs) and aminoacyl-tRNA synthetases, has led to both biotechnology products (i.e.,...
Keyword:: Genome engineering, Directed evolution, Synthetic biology, and Cell chassis development
Subject:: Bioengineering and Chemical engineering
Creator:: Gowland, Samuel Luke Walker
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16336 and etdadmin_upload_943800

Description:: Biological therapeutics have revolutionized the way we treat cancer due to their ability to target tumors discriminately, leaving healthy cells unaffected. However, our inability to tailor the structure of biologics may hamper their optimization for efficacy. This lack of programmability contributes to factors such as immunogenic responses, inability to penetrate...
Keyword:: Nanotechnology, Cancer therapy, Synthetic biology, Synthetic chemistry, Protein engineering, and Protein scaffolds
Subject:: Bioengineering, Chemistry, and Chemical engineering
Creator:: Kimmel, Blaise Russel
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_852716 and http://dissertations.umi.com/northwestern:15804

Description:: Cell-based therapies are an exciting frontier in medicine. This field is built on a simple premise—cells can be engineered to recognize and treat various human diseases. The paradigm of cell-based therapy uses biosensors to interrogate a cell’s environment and distinguish disease from health, intracellular signaling pathways and genetic circuitry to...
Keyword:: Cell-based therapy, Synthetic receptors, Synthetic biology, Biosensors, Transcription factors, and Immunotherapy
Subject:: Bioengineering, Biology, and Medicine
Creator:: Donahue, Patrick Sean
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Modified:: 05/06/2022
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15420 and etdadmin_upload_781062

Description:: Metabolite biosensors are powerful tools for basic biological research, medical diagnostics, and biotechnological applications. However, a generalizable strategy for developing new metabolite biosensors when an existing sensor cannot be found in nature, is a persistent challenge. Furthermore, while transcription factor biosensors have the broadest range of applications, the pool of...
Keyword:: Bioengineering, Transcription factor, Synthetic biology, Promoter engineering, Protein engineering, and Metabolic engineering
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Andrew Younger
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/18/2018
Date Modified:: 04/18/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

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