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Inhibitors of the Ubiquitin Ligase Nedd4-1 Discovered by Covalent Fragment Screening

Description:

The FDA approvals of afatinib and ibrutinib in 2013 led to a heightened interest in cysteine-reactive covalent inhibitors. However, there are few methods to discover new cysteine-reactive inhibitors for enzymes for which reversible binding scaffolds are not known. To this end, we rationally designed a chemical system to attach a...

Keyword:

Electrophile, Covalent, Fragment, Ubiquitin, and Nedd4-1

Subject:

Chemistry

Creator:

Stefan Kathman

Owner:

Scholarly Digital Publishing

Date Uploaded:

02/19/2018

Date Modified:

02/19/2018

Date Created:

2016-01-01

Resource Type:

Dissertation
Foxp3-specific Deubiquitinase Modules enhance Treg fitness

Description:

Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumor immunity. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties, can promote autoimmunity and/or facilitate more effective tumor immunity. A comprehensive understanding...

Keyword:

Tumor, Treg, Ubiquitin, Foxp3, Usp21, and Usp22

Subject:

Biology, Cellular biology, and Immunology

Creator:

Montauti, Elena

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_846345 and http://dissertations.umi.com/northwestern:15780

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Inhibitors of the Ubiquitin Ligase Nedd4-1 Discovered by Covalent Fragment Screening

Foxp3-specific Deubiquitinase Modules enhance Treg fitness

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