Small, soluble, self-assembling peptide Aβ-oligomers, known as ADDLs
(amyloid-derived diffusible ligands), accumulate in the Alzheimer’s
disease (AD) brain as Aβ 12-mers and are thought to contribute to AD
neuropathological conditions. Unlike plaques, which were once thought
to cause neuronal death due to insoluble amyloid plaque deposits,
ADDLs initiate abnormal changes...
With the advent of a variety of novel nanometer-scale diagnostic techniques such as DNA micro- and nanoarrays, increasing focus has been placed on developing methods to quickly and accurately create these nanometer scale patterns. One promising technique for depositing DNA, proteins, and other liquid molecular "inks" with submicron resolution is...