Neurons are difficult to manipulate experimentally. Most transfection
reagents used for gene silencing are neurotoxic, and the postmitotic
state of neurons prevents the effective use of viral vectors. This study
demonstrated the delivery of antisense DNA against target genes by
gold nanoparticle oligonucleotide complexes (GNOs) in primary cultures
of rat...
Magnetic nanostructures (MNS) have become the subject of intense
interest due to their superparamagnetic properties and consequently
their potential uses in medical diagnostics and therapeutics. In this
study, monodisperse magnetite MNSs were synthesized via thermal
decomposition of iron(III) acetylacetonate and transferred to aqueous
solution using 11-aminoundecanoic acid as the surfactant....