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Modeling Cell Protrusion by a Population of Actin Filaments

Description:

Actin polymerization is responsible for the protrusion of filopodia and lamellipodia in immune, cancer, and other motile cells, as well as for propulsion of some intra cellular pathogens. Protrusion of a lamellipodium by the very filaments supporting the membrane load operates by the Brownian ratchet mechanism, with overall organization governed...

Keyword:

simulation, energetics, protrusion, actin, lamellipodium, and stochastic

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Thomas Schaus

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/30/2018

Date Modified:

08/30/2018

Date Created:

2007-12-10

Resource Type:

Dissertation
Barbed End Regulation and the Formation of Actin Protrusive Structures

Description:

Barbed end regulation is critical to the formation of the actin-based protrusive structures, lamellipodia and filopodia. In this body of work we have chosen to focus on two main activities, filament termination by the heterodimeric Capping protein (CP) and continued filament elongation by the Ena/VASP family of proteins. We demonstrate...

Keyword:

actin protrusive structures, lamellipodia, filopodia, Ena/VASP, Capping Protein, and actin

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Derek Anthony Applewhite

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/02/2018

Date Modified:

08/02/2018

Date Created:

2007-09-04

Resource Type:

Dissertation

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Modeling Cell Protrusion by a Population of Actin Filaments

Barbed End Regulation and the Formation of Actin Protrusive Structures

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