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Description:: Breast cancer cells acquire many genetic alterations in apoptotic signaling pathways rendering them resistant to apoptosis. Human Epidermal growth factor Receptor-2 (HER-2/ErbB2/neu) is amplified or overexpressed in approximately 30% of breast and ovarian tumors and correlates with poor prognosis. Although HER-2 is an orphan receptor, it forms potent signaling heterodimers...
Keyword:: HER-2/neu, apoptosis, BH3, caspase substrates, and breast cancer
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Anne Marie Strohecker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 07/30/2018
Date Modified:: 07/30/2018
Date Created:: 05-15-2007
Resource Type:: Dissertation

Description:: Little is known about the transcriptional events underlying megakaryocytic (Mk) differentiation from hematopoietic stem cells. We sought to identify genes and pathways not previously associated with megakaryopoiesis and to evaluate the CHRF-288-11 (CHRF) megakaryoblastic cell line as a model system for investigating megakaryopoiesis. Using DNA microarrays, Q-RT-PCR, and protein-level assays,...
Keyword:: p53, microarray, differentiation, apoptosis, polyploidization, and megakaryocyte
Subject:: Chemical and Biological Engineering
Creator:: Peter Gebhard Fuhrken
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/06/2018
Date Modified:: 08/06/2018
Date Created:: 2007-07-12
Resource Type:: Dissertation

Description:: Phagocytosis is an essential mechanism for clearance of pathogens, dying cells, and other unwanted debris in order to maintain tissue health in the body. Macrophages execute this process in the peripheral immune system, but in the brain microglia act as resident macrophages to accomplish this function. In the peripheral immune...
Keyword:: MFG-E8, phagocytosis, apoptosis, Gas6, Alzheimer's disease, and microglia
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Abby Denise Fuller
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/14/2018
Date Modified:: 09/14/2018
Date Created:: 2008-08-11
Resource Type:: Dissertation

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