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  1. The modulation of MFG-E8 mediated microglial phagocytosis

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    Description: Phagocytosis is an essential mechanism for clearance of pathogens, dying cells, and other unwanted debris in order to maintain tissue health in the body. Macrophages execute this process in the peripheral immune system, but in the brain microglia act as resident macrophages to accomplish this function. In the peripheral immune...
    Keyword: phagocytosis, MFG-E8, apoptosis, Alzheimer's disease, Gas6, and microglia
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Abby Denise Fuller
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/14/2018
    Date Modified: 09/14/2018
    Date Created: 2008-08-11
    Rights: In Copyright
    Resource Type: Dissertation
  2. Genome-Scale Transcriptional Analysis of Megakaryocytic Cell Cultures Reveals Insights into Lineage-Specific Differentiation

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    Description: Little is known about the transcriptional events underlying megakaryocytic (Mk) differentiation from hematopoietic stem cells. We sought to identify genes and pathways not previously associated with megakaryopoiesis and to evaluate the CHRF-288-11 (CHRF) megakaryoblastic cell line as a model system for investigating megakaryopoiesis. Using DNA microarrays, Q-RT-PCR, and protein-level assays,...
    Keyword: polyploidization, microarray, apoptosis, p53, differentiation, and megakaryocyte
    Subject: Chemical and Biological Engineering
    Creator: Peter Gebhard Fuhrken
    Owner: Scholarly Digital Publishing
    Date Uploaded: 08/06/2018
    Date Modified: 08/06/2018
    Date Created: 2007-07-12
    Rights: In Copyright
    Resource Type: Dissertation
  3. Caspase cleavage of HER-2/neu Releases a BH3-like Cell Death Effector

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    Description: Breast cancer cells acquire many genetic alterations in apoptotic signaling pathways rendering them resistant to apoptosis. Human Epidermal growth factor Receptor-2 (HER-2/ErbB2/neu) is amplified or overexpressed in approximately 30% of breast and ovarian tumors and correlates with poor prognosis. Although HER-2 is an orphan receptor, it forms potent signaling heterodimers...
    Keyword: HER-2/neu, breast cancer, apoptosis, caspase substrates, and BH3
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Anne Marie Strohecker
    Owner: Scholarly Digital Publishing
    Date Uploaded: 07/30/2018
    Date Modified: 07/30/2018
    Date Created: 05-15-2007
    Rights: In Copyright
    Resource Type: Dissertation