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Novel Roles of the E2F-2 Transcription Factor and Regulation of Cyclin E in Promoting Terminal Erythroid Maturation

Description:

E2F-2 is a Retinoblastoma (Rb)-regulated transcription factor induced during terminal erythroid maturation. Cyclin E-mediated Rb hyper-phosphorylation induces E2F transcriptional activator functions. E2F-2-loss causes reduced peripheral red blood cell (RBC) counts, without altering relative abundances of erythroblast subpopulations. To determine how E2F-2 regulates RBC production, we comprehensively studied erythropoiesis using knockout...

Keyword:

cellular biology, Biology, and molecular biology

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Kelsey Swartz

Owner:

Scholarly Digital Publishing

Date Uploaded:

02/19/2018

Date Modified:

02/19/2018

Date Created:

2016-01-01

Resource Type:

Dissertation