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Identifying Molecular Pathways Linking Circadian Rhythms and Neurodegeneration

Description:

Neurodegenerative diseases (NDs) commonly involve the accumulation and aggregation of neurotoxic proteins that impair and ultimately destroy specific neurons. Considerable evidence from human and animal studies indicates that many NDs show disrupted circadian and sleep as symptoms. Yet little is known about the molecular mechanisms by which genes cause NDs...

Keyword:

genetic screen, neurodegeneration, Huntington’s disease, and circadian

Subject:

Biology and Neurosciences

Creator:

Xu, Fangke

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14655 and etdadmin_upload_662687
Differential Effects of Physiological Temperature Changes on Central Versus Peripheral Circadian Clocks in Mice.

Description:

Most organisms use rhythms of sunlight to synchronize their activity to the environment. These rhythms of activity are called circadian rhythms. The rhythms persist with near 24 hour periods when external synchronizing cues are absent. In mammals, the circadian clock is generated at the molecular level by a transcriptional/translational feedback...

Keyword:

SCN, mouse, Heat Shock Factor, body temperature, circadian, and suprachiasmatic nucleus

Subject:

Neuroscience Institute Graduate Program

Creator:

Ethan Buhr

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/20/2018

Date Modified:

09/20/2018

Date Created:

2008-11-25

Resource Type:

Dissertation

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Identifying Molecular Pathways Linking Circadian Rhythms and Neurodegeneration

Differential Effects of Physiological Temperature Changes on Central Versus Peripheral Circadian Clocks in Mice.

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