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Direct Reprogramming of Human Cells to a Cardiomyocyte-Like State

Description:

The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts. However, this process has been less successful in human cells, thus limiting the potential clinical applicability of this technology in regenerative medicine. We hypothesized that this issue is due...

Keyword:

calcium cycling, spontaneous contraction, high-throughput, cardiomyocyte, direct reprogramming, and fibroblast

Subject:

Biology, Cellular biology, and Developmental biology

Creator:

Romero Tejeda, Marisol

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

05/31/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_970274 and http://dissertations.umi.com/northwestern:16446