Chronic stress is a significant risk factor for the development of numerous psychiatric disorders, including major depressive disorder (MDD). Individuals with MDD exhibit impairments in reward processing and decreased motivation to engage in previously-rewarding activities. Importantly, there is a large sex disparity in MDD diagnosis, such that it affects nearly...
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, causing devastating disabilities in both motor and non-motor domains following the degeneration of dopamine (DA) producing neurons of the substantia nigra pars compacta (SNc). Current treatments are highly limited in efficacy, and no established treatments currently exist to alter disease...