The polymerization of the microtubule-associated protein, tau, into insoluble filaments is common to Alzheimer's disease (AD) and in a variety of dementias. The conformational change required for tau to transition from soluble monomers to filamentous AD pathology involves the extreme N-terminus of tau coming into contact with other regions of...
"Anosognosia" or lack of insight into one's own illness is not uncommon in central nervous system disease. Neurodegenerative diseases of the brain that cause dementia are often associated with anosognosia. A lot is known about anosognosia in Alzheimer's disease but relatively little is known about lack of insight into illness...