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Neuroinflammation in an Alzheimer's Disease Animal Model and the Effectiveness of Selective Suppression of Glial Activation

Description:

There is increasing evidence that links chronic activation of glial cells and the subsequent self-propagating cycle of neuroinflammation to the neurodegenerative progression of Alzheimer's disease (AD). Nevertheless, attempts to identify currently approved drugs capable of safely attenuating the neuroinflammatory processes in AD have proven disappointing to date, and the development...

Keyword:

neuroinflammation, beta-amyloid, glia, and Alzheimer's disease

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Jeffrey Michael Craft

Owner:

Scholarly Digital Publishing

Date Uploaded:

05/10/2018

Date Modified:

05/10/2018

Date Created:

2007-03-05

Resource Type:

Dissertation
Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

Description:

Early-life seizures increase susceptibility to seizures in adulthood. However, mechanisms by which seizures in the developing brain lead to increased vulnerability to seizures and exacerbation of neurological injury in adulthood remain unknown. We test the hypothesis that upregulation of proinflammatory cytokine levels and chronic glial activation following early-life seizures result...

Keyword:

seizures, cytokines, microglia, glia, glutamate, and neuroinflammation

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Kathleen Cua Somera-Molina

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/27/2018

Date Modified:

08/27/2018

Date Created:

2007-12-07

Resource Type:

Dissertation

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Neuroinflammation in an Alzheimer's Disease Animal Model and the Effectiveness of Selective Suppression of Glial Activation

Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

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