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Serine metabolism supports macrophage IL-1beta production.

Description:

Some of the oldest drugs targeting metabolism are the antifolates such as aminopterin and methotrexate (MTX). MTX started being used in the 1950s to treat rheumatoid arthritis. Aminopterin and MTX both target one carbon metabolism and inhibit proliferation of cells. MTX was a potent inhibitor of inflammation, because it prevented...

Keyword:

macrophage, LPS, glutathione, metabolism, inflammation, and serine

Subject:

Biology

Creator:

Rodriguez, Arianne

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_638528 and http://dissertations.umi.com/northwestern:14513
Metabolic Reprogramming of Macrophage During Inflammation Resolution and Cardiac Wound Healing

Description:

Macrophages are one of the most versatile immune cells in the immune system. They are found in nearly every tissue and organ throughout the body. Macrophages play important roles of orchestrating initiation and resolution of inflammation, such as sentineling against pathogens or engulfing apoptotic cells. Macrophages are able to respond...

Keyword:

macrophage, cardiovascular diseases, inflammation, and metabolism

Subject:

Immunology

Creator:

Zhang, Shuang

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_623187 and http://dissertations.umi.com/northwestern:14427

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Serine metabolism supports macrophage IL-1beta production.

Metabolic Reprogramming of Macrophage During Inflammation Resolution and Cardiac Wound Healing

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