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Description:: Although centrosomes nucleate and organize microtubules in mitotically-dividing cells, spindles in female reproductive cells (oocytes) form in their absence. In some organisms acentrosomal spindle assembly is mediated by acentriolar microtubule organizing centers (MTOCs) that are thought to functionally replace centrosomes. However, spindle assembly in human oocytes does not require MTOCs;...
Keyword:: acentrosomal, meiosis, acentriolar, kinesin, microtubule, and C. elegans
Subject:: Molecular biology, Biochemistry, and Cellular biology
Creator:: Wolff, Ian
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_763687 and http://dissertations.umi.com/northwestern:15248

Description:: Kinesin-1 is a motor protein that transports cargo along microtubules. Inside cells, the majority of kinesin-1 is regulated to conserve ATP and ensure its proper intracellular distribution and coordination with other motors. Regulated kinesin-1 is folded in half, and interactions between coiled-coil regions near the N-terminal enzymatically active heads and...
Keyword:: kinesin and regulation
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Kristen Dietrich
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/14/2018
Date Modified:: 09/14/2018
Date Created:: 2008-11-04
Resource Type:: Dissertation

Description:: In several neurodegenerative diseases, the microtubule-associated protein tau self-aggregates to form filaments that accumulate in neurons and/or glia, although the relationship between tau aggregation and cell death is a subject of debate. The amino terminus of tau is involved in conformational changes that appear critical for filament formation, hinting at...
Keyword:: filament, axonal transport, kinesin, Alzheimer's disease, and tau
Subject:: Neuroscience Institute Graduate Program
Creator:: Nichole LaPointe
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/06/2018
Date Modified:: 09/06/2018
Date Created:: 2008-02-21
Resource Type:: Dissertation

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