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Tailoring Modular Spherical Nucleic Acids for DNA and RNA Delivery

Description:

Nucleic acids such as DNA or RNA of various lengths and structures have a wide scope of functions as therapeutic entities compared to conventional drugs. For instance, native and modified forms of nucleic acids can be used for gene silencing, genome editing, gene replacement, immune system modulation, and theranostics. While...

Keyword:

lipids, drug delivery, DNA, RNA, and nanoparticles

Subject:

Biomedical engineering

Creator:

Sinegra, Andrew

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_845229 and http://dissertations.umi.com/northwestern:15759
Cancer-Associated Isocitrate Dehydrogenase 1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Description:

Metabolic abnormalities of cancers provide opportunities for novel tumor-specific therapies. Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate (αKG) and the reduction of NAD(P)+ to NAD(P)H. Oncogenic mutations in two IDH-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and secondary glioblastoma...

Keyword:

lipids, Glioblastoma (GBM), targeted therapy, wild-type IDH1, NADPH, and metabolism

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Andrea Calvert

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/27/2018

Date Modified:

04/27/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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Tailoring Modular Spherical Nucleic Acids for DNA and RNA Delivery

Cancer-Associated Isocitrate Dehydrogenase 1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

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