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Cell Culture Systems Inspired by the Hematopoietic Stem Cell Niche

Description:

The hematopoietic stem cell (HSC) niche is the site where HSCs reside in vivo. The HSC niche is formed by supporting cells that provide structure and appropriate environmental cues for HSCs. In this study, three components of the HSC niche were evaluated for their influence on HSC expansion ex vivo:...

Keyword:

thrombopoietin mimetic, reduced oxygen tension culture, lipopeptide, hematopoietic stem cell culture, and stem cell factor

Subject:

Chemical and Biological Engineering

Creator:

James A King

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/27/2018

Date Modified:

08/27/2018

Date Created:

2007-09-04

Resource Type:

Dissertation
Strategies for Immobilization of Cell Adhesion Molecule and Cytokine Receptor Ligands: Inspiration from the Cell Membrane and Marine Mussels

Description:

Cells are regulated by a combination of soluble stimuli and adhesive interactions with other cells and the extracellular matrix (ECM). We are developing systems to present ECM and cytokine receptor ligands in a defined manner for applications in hematopoietic stem and progenitor cell (HSPC) culture. We hypothesize that the controlled,...

Keyword:

polydopamine, CD34+ hematopoietic progenitor cell, lipid membrane, lipopeptide, and glycosaminoglycan

Subject:

Chemical and Biological Engineering

Creator:

Shara Marie Dellatore

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/14/2018

Date Modified:

09/14/2018

Date Created:

2008-11-25

Resource Type:

Dissertation

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Cell Culture Systems Inspired by the Hematopoietic Stem Cell Niche

Strategies for Immobilization of Cell Adhesion Molecule and Cytokine Receptor Ligands: Inspiration from the Cell Membrane and Marine Mussels

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