Index Catalog // Arch : Northwestern University Institutional Repository

Description:: The NLRP3 inflammasome is a multi-protein complex that drives sterile and pathogen-dependent inflammation. Activation of the NLRP3 inflammasome occurs in two steps: priming and activation. Priming occurs in response to an inflammatory stimulus, such as LPS. LPS-primed macrophages are subsequently activated by a second stimuli, most of which require K+...
Keyword:: macrophage, mitochondria, immunometabolism, inflammasome, and metabolism
Subject:: Biology
Creator:: Billingham, Leah Katherine
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15953 and etdadmin_upload_882213

Description:: Macrophages are innate immune cells that are traditionally thought to be specialists in phagocytosis. More recent evidence suggest that macrophages reside in nearly every organ and readily adapt to local microenvironmental signals, leading to highly plastic phenotypes across and within tissues. Therefore, rather than treating it as a homogenous cell...
Keyword:: macrophage, bioinformatics, and NGS
Subject:: Bioinformatics and Biology
Creator:: Chen, Shang-Yang
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16027 and etdadmin_upload_900059

Description:: This dissertation focuses on the development of quantitative approaches for characterizing endogenous signaling pathways and designing new pathways in mammalian cells. I demonstrate how mathematical descriptions that are formulated to explain gene expression patterns can also serve as a powerful springboard for deeper analyses into the properties and functions of...
Keyword:: macrophage, systems biology, receptor, computational biology, transcription factor, and synthetic biology
Subject:: Bioengineering, Molecular biology, and Immunology
Creator:: Muldoon, Joseph Jacob
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15256 and etdadmin_upload_764084

Description:: Some of the oldest drugs targeting metabolism are the antifolates such as aminopterin and methotrexate (MTX). MTX started being used in the 1950s to treat rheumatoid arthritis. Aminopterin and MTX both target one carbon metabolism and inhibit proliferation of cells. MTX was a potent inhibitor of inflammation, because it prevented...
Keyword:: macrophage, LPS, glutathione, metabolism, inflammation, and serine
Subject:: Biology
Creator:: Rodriguez, Arianne
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_638528 and http://dissertations.umi.com/northwestern:14513

Description:: Macrophages are one of the most versatile immune cells in the immune system. They are found in nearly every tissue and organ throughout the body. Macrophages play important roles of orchestrating initiation and resolution of inflammation, such as sentineling against pathogens or engulfing apoptotic cells. Macrophages are able to respond...
Keyword:: macrophage, cardiovascular diseases, inflammation, and metabolism
Subject:: Immunology
Creator:: Zhang, Shuang
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_623187 and http://dissertations.umi.com/northwestern:14427

Description:: The orderly process of hematopoietic differentiation is governed in large part by the coordinated transcription of specific genes. Deregulation of normal differentiation processes can lead to disease states including immunodeficiency, autoimmune disease, and leukemia. This research focuses on the family of transcription factors known as the early growth response (Egr)...
Keyword:: Egr, macrophage, transcription, and thymocyte
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: John Carter
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/12/2018
Date Modified:: 09/12/2018
Date Created:: 2008-05-09
Resource Type:: Dissertation

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