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Genome-Scale Transcriptional Analysis of Megakaryocytic Cell Cultures Reveals Insights into Lineage-Specific Differentiation

Description:

Little is known about the transcriptional events underlying megakaryocytic (Mk) differentiation from hematopoietic stem cells. We sought to identify genes and pathways not previously associated with megakaryopoiesis and to evaluate the CHRF-288-11 (CHRF) megakaryoblastic cell line as a model system for investigating megakaryopoiesis. Using DNA microarrays, Q-RT-PCR, and protein-level assays,...

Keyword:

p53, microarray, differentiation, apoptosis, polyploidization, and megakaryocyte

Subject:

Chemical and Biological Engineering

Creator:

Peter Gebhard Fuhrken

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/06/2018

Date Modified:

08/06/2018

Date Created:

2007-07-12

Resource Type:

Dissertation
Data-Driven Strategies for Optimization of Human Megakaryocyte Differentiation

Description:

Platelets are circulating anucleate discs derived from megakaryocytes, and play major roles in hemostasis, inflammation, thrombosis, and vascular biology. Multi-phase culture systems for inducing in vitro platelet production from mature megakaryocytes have been explored to allow progenitor expansion, megakaryocyte maturation, and promotion of platelet formation and shedding. In this thesis,...

Keyword:

gaussian mixture models, stem cell differentiation, machine learning, and megakaryocyte

Subject:

Bioengineering, Bioinformatics, and Biology

Creator:

WU, JIA JIE

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_640286 and http://dissertations.umi.com/northwestern:14541

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Genome-Scale Transcriptional Analysis of Megakaryocytic Cell Cultures Reveals Insights into Lineage-Specific Differentiation

Data-Driven Strategies for Optimization of Human Megakaryocyte Differentiation

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