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  1. The modulation of MFG-E8 mediated microglial phagocytosis

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    Description: Phagocytosis is an essential mechanism for clearance of pathogens, dying cells, and other unwanted debris in order to maintain tissue health in the body. Macrophages execute this process in the peripheral immune system, but in the brain microglia act as resident macrophages to accomplish this function. In the peripheral immune...
    Keyword: microglia, phagocytosis, MFG-E8, apoptosis, Gas6, and Alzheimer's disease
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Abby Denise Fuller
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/14/2018
    Date Modified: 09/14/2018
    Date Created: 2008-08-11
    Rights: In Copyright
    Resource Type: Dissertation
  2. Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

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    Description: Early-life seizures increase susceptibility to seizures in adulthood. However, mechanisms by which seizures in the developing brain lead to increased vulnerability to seizures and exacerbation of neurological injury in adulthood remain unknown. We test the hypothesis that upregulation of proinflammatory cytokine levels and chronic glial activation following early-life seizures result...
    Keyword: cytokines, glutamate, seizures, microglia, neuroinflammation, and glia
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Kathleen Cua Somera-Molina
    Owner: Scholarly Digital Publishing
    Date Uploaded: 08/27/2018
    Date Modified: 08/27/2018
    Date Created: 2007-12-07
    Rights: In Copyright
    Resource Type: Dissertation